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Department of Biochemistry and Biophysics

The Department of Biochemistry and Biophysics, established in 1981, conducts M.Sc. course in Biochemistry and M.Sc. course in Biophysics, i.e., the two M.Sc. courses have been running under one roof of the Department . Department has intake capacity of twenty (20) students for M.Sc. course in Biochemistry and twenty (20) students for M.Sc course in Biophysics. The Departmental Faculties have been involved in teaching and research in Basic Biochemistry, Basic Biophysics, Cell Biology, Microbiology, Molecular Biology, Genetics, Immunology,  Cellular Signaling, Biochemistry of host parasite interactions, X-ray crystallography, Molecular Modeling, Bio-informatics etc. Faculty members of the department are also involved in strengthening other related Departments of the University by taking postgraduate classes and helping their research activities. Presently, forty three (43) students have been carrying out their research works under supervision of the Departmental faculties. The Department has already gained attention from leading scientists and academicians at the National and Internation levels. The Department of Science and Technology (DST), Government of India, has identified this Department under the FIST (Fund for Improvement of S&T Infrastructure in Universities and other Higher Educational Institutions) Program. UGC has also identified this Department under SAP.

Head of the Department:
Prof. Tarakdas Basu

Departmental Phone No.
(033) 2582 8750(033) 2582 8750 (Ext. 293, 294)

Departmental E-mail Address:
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Degree & Courses Offered :

Type of course

Name of course duration

Duration

Classes per week

Intake capacity

Eligibility

Post graduate

M.Sc in Biochemistry

2 years

20- theory

20- practical

20

B.Sc(Hons) in Chemistry with Physics & Mathematics

M.Sc in Biophysics

2 years

20- theory

20- practical

20

B.Sc(Hons) in Physics with Chemistry & Mathematics

Doctoral Degree

Ph.D in Biochemistry

5 years approx.

-

Flexible

Any branch of science

Ph.D in Biophysics

5 years approx.

-

Flexible

Any branch of science

Post doctoral research

D.Sc in Biochemistry

Flexible

-

Flexible

Any branch of science

D.Sc in Biophysics

Flexible

-

Flexible

Any branch of science

Focus and Thrust areas of  the Department of Biochemistry and Biophysics

The Department offers two degrees: One MSc in Biochemistry and MSc in Biophysics. The focus of teaching and research of the Department is, therefore, associated with different fields of Biochemistry and Biophysics.
The focus of teaching in Biochemistry and Biophysics underlies mainly with the understanding the nature and characteristics of different biomolecules and their structural, metabolic, molecular and genetic aspects in microbial, plant and animal systems.
The following are the thrust areas of research of the faculty members of the Department: 

1. Understanding biochemical mechanisms in regulating pulmonary vascular tone under oxidant and calcium signaling phenomena by the vasoactive mediators such as thromboxane A2, endothelin-1, angiotensin II, leukotriene D4 etc.
2.  Effect of chronic oxidative stress in mammalian cells.   
3. Structural and biophysical studies on the mechasnism of induction of heat-shock proteins in E.Coli.
4. Molecular and cellular mechanisms underlying the sustained metal tolerance of fungi.
5. Protein-ligand interaction by x-ray crystallographic studies and modeling studies of membrane systems.                                                                                                                             
6. Studies on the binding patters of  different nanoparticles and development of their biosensors.
7. Role of different proteases in the pathogenesis of visceral leishmaniasis and the efficacy of different natural products as therapeutic measure to combat leishmaniasis.
8. Studies on the effects of microwave radiation on cultured mammalian cells.
9. Studies on the biological activities of some synthetic and natural products to characterize their anti-cancer activities.
10. Studies on bystander effect of UV-radiation.
11. In-silico characterization of formin binding protein 4 and their interactions with formins.
12. Study on the role of actin binding proteins in molecular dystrophies from structural view point.
13. Supramolecular chemistry: Study of self-association of peptide based molecules: elucidation of molecular assembly, mechanism, designing of nano dimension materials, novel biomaterials as well as biological applications of self-assembled system.


Programme of Study

Ph.D. – to a maximum of 8 research Scholars per teacher (as per the University norm)

M.Phil. - Nil

M.Sc. in Biochemistry – 20 students per semester

M.Sc. in Biophysics - 20 students per semester

Any other degree/ Diploma – Ph.D. course work [number is variable according to existing no. of Research scholars working at the time(who have not completed their course work)]

Events of the Department for 2012 – 2013:

i) Prof. J.J.Ghosh Memorial Lecture and Prof. A. N. Bhaduri Memorial Lecture held on 10th December, 2012

ii) Prof. A.G.Dutta Memorial Lecture held on 31st December, 2012

iii) Prof. A.K.Bhattacharya and Prof. N.N.Dasgupta Memorial Lectures held on 13 February, 2014

 

Funding received during the period/ Amount / purpose/ agency:

i) UGC 12th Plan (1st Phase) Grant

Equipment : Rs. 3 lakhs ; Books and Journal : Rs 1.2 lakh

ii) UGC- SAP

Equipment : Rs 40 lakhs

iii) BIF facility for the Department (Supported by DBT, Gov. of India): Rs 12.0 lakhs (2012-13)

iv) Individual Projects (on going):

Sl. No.

Name of the Faculty

Title of   ongoing project

(as the principal investigator)

Funding Agency

Amount

1.

Prof. Sajal Chakraborti

1. Studies on signal transduction mechanisms associated with ONOO- mediated regulation of β-adrenergic response in pulmonary smooth muscle cells

2. Studies on phonapholemman phosphrylation by protein kinase A and protein kinase C in regulating [Ca2+] by α1β1 and α2β1 isozymes of Na+/Ca+2 exchanger in caveeolae (signalosomes) pulmonary artery smooth muscle cells.

3. Study on the mechanism(s) by which thromboxane A2 inhibits β-adrenergic response in pulmonary artery smooth muscle cells.

DBT, Govt. of India

1.1.2011-1.4.2014

 

 

 

 

CSIR, Govt. of India

1.4.2012-31.3.2015

 

 

 

 

 

 

 

DAE,Govt. of India

15.12.2011-31.3.2014

37lakh

 

 

 

 

 

19lakh

 

 

 

 

 

 

 

 

18lakh

2.

Prof. Tarakdas Basu

Roles of chaperone protein GroEL and outer membrane proteins OmpA/C on the entry of DNA in the CaCl2-mediated transformation process of E. coli with extraneous DNA.

U G C, New Delhi

1.1.2013-31.3.2016

13.262 Lakhs

3

Dr. Tapati Chakraborti

1.Studies on Leishmania donovani secretory serine protease in host-parasite interactions and immunemodulation of visceral leishmaniasis.

2. Studies on naturally occurring serine protease inhibitor(s) from Coccinia grandis (L) Voigt               in the modulation of host cell signaling and cellular invasion by Leishmania donovani.

CSIR , Govt. of India

01.11.2012-31.10.2015

 

 

 

 

DAE, Govt of India

13.05.2013 – 12.05.2016

16.0 lakh

 

 

 

 

 

24 lakh-

4.

Dr. Rakhi Dasgupta

Structural insight into the interactions of the heat shock proteins and heat shock transcription factor s32 in E. coli

DBT, Govt. of India

24.5.2013-23.5.2016

16,95000.24

5.

Dr. Utpal  Ghosh

1. Role of Poly(ADP-ribose) polymerase-1 (PARP-1) in regulating expression and activity of matrix metalloproteinase (MMP) and its tissue inhibitors (TIMP) with and without carbon ion beam irradiation.

 

2.Functional characterization of interaction of poly(ADP-ribose)polymerase 1 (PARP-1) with telomere-binding proteins.

 

3. Regulation of biogenesis of Telomeric RNA and its role in telomere length maintenance,

ICMR, New Delhi. Gov. of India

01.04.2011 to 31.03.2014.

 

 

 

 

DST, Govt. of India 01.09.2012 to 31.08.2015

 

 

 

DBT, Govt. of India 03.06.2013 to 02.06.2016

8.8 Lakh

 

 

 

 

 

 

 

27 Lakh

 

 

 

 

45 Lakh

6.

Dr. Jishu Naskar

Peptide based Biomaterials: Fabrication and Applications

UGC, New Delhi

30-12.2013-29.12.2015

6 Lakh

Proposed intake for 2013-2014 academic year:  Biochemistry -20 ; Biophysics-20

Any RTI received replied:  Nil

Future Projection for 2013- 2014:

i) Integrated (B.Sc. and M.Sc.) courses in Biochemistry and Biophysics

ii) Creation of Bioinformatics Centre under the Department of Biochemistry and Biophysics

iii) Creation of Centre for Molecular Medicine under the Department of Biochemistry and Biophysics

          

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